BCL6.H12RSNP.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	BCL6.H12RSNP.0.PSM.A
Gene (human)	BCL6 (GeneCards)
Gene synonyms (human)	BCL5, LAZ3, ZBTB27, ZNF51
Gene (mouse)	Bcl6
Gene synonyms (mouse)	Bcl-6
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	13
Consensus	bbMYYTCbAGGAA
GC content	46.04%
Information content (bits; total / per base)	12.208 / 0.939
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	66

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	10 (67)	0.749	0.917	0.698	0.91	0.745	0.914	2.834	4.995	92.409	608.201
Mouse	15 (93)	0.771	0.923	0.694	0.89	0.773	0.946	2.861	4.686	88.046	179.469

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.999	0.999	0.954	0.956	0.79	0.821
Overall, 2 experiments	best	1.0	1.0	0.997	0.996	0.87	0.887
Methyl HT-SELEX, 1 experiments	median	1.0	1.0	0.997	0.996	0.87	0.887
Methyl HT-SELEX, 1 experiments	best	1.0	1.0	0.997	0.996	0.87	0.887
Non-Methyl HT-SELEX, 1 experiments	median	0.998	0.998	0.911	0.915	0.709	0.754
Non-Methyl HT-SELEX, 1 experiments	best	0.998	0.998	0.911	0.915	0.709	0.754

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	21.513	4.465	0.39	0.294

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	BCL6 {2.3.3.22} (TFClass)
TFClass ID	TFClass: 2.3.3.22.2
HGNC	HGNC:1001
MGI	MGI:107187
EntrezGene (human)	GeneID:604 (SSTAR profile)
EntrezGene (mouse)	GeneID:12053 (SSTAR profile)
UniProt ID (human)	BCL6_HUMAN
UniProt ID (mouse)	BCL6_MOUSE
UniProt AC (human)	P41182 (TFClass)
UniProt AC (mouse)	P41183 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	10 human, 15 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	BCL6.H12RSNP.0.PSM.A.pcm
PWM	BCL6.H12RSNP.0.PSM.A.pwm
PFM	BCL6.H12RSNP.0.PSM.A.pfm
Alignment	BCL6.H12RSNP.0.PSM.A.words.tsv
Threshold to P-value map	BCL6.H12RSNP.0.PSM.A.thr
Motif in other formats
JASPAR format	BCL6.H12RSNP.0.PSM.A_jaspar_format.txt
MEME format	BCL6.H12RSNP.0.PSM.A_meme_format.meme
Transfac format	BCL6.H12RSNP.0.PSM.A_transfac_format.txt
Homer format	BCL6.H12RSNP.0.PSM.A_homer_format_0.001.txt BCL6.H12RSNP.0.PSM.A_homer_format_0.0005.txt BCL6.H12RSNP.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	6.0	16.0	21.0	23.0
02	7.0	8.0	34.0	17.0
03	12.0	42.0	6.0	6.0
04	4.0	13.0	2.0	47.0
05	3.0	15.0	7.0	41.0
06	2.0	5.0	1.0	58.0
07	0.0	54.0	3.0	9.0
08	5.0	29.0	9.0	23.0
09	65.0	0.0	1.0	0.0
10	9.0	1.0	56.0	0.0
11	3.0	6.0	57.0	0.0
12	60.0	1.0	4.0	1.0
13	56.0	0.0	4.0	6.0

PFM

	A	C	G	T
01	0.091	0.242	0.318	0.348
02	0.106	0.121	0.515	0.258
03	0.182	0.636	0.091	0.091
04	0.061	0.197	0.03	0.712
05	0.045	0.227	0.106	0.621
06	0.03	0.076	0.015	0.879
07	0.0	0.818	0.045	0.136
08	0.076	0.439	0.136	0.348
09	0.985	0.0	0.015	0.0
10	0.136	0.015	0.848	0.0
11	0.045	0.091	0.864	0.0
12	0.909	0.015	0.061	0.015
13	0.848	0.0	0.061	0.091

PWM

	A	C	G	T
01	-0.912	-0.029	0.228	0.315
02	-0.78	-0.662	0.692	0.028
03	-0.296	0.897	-0.912	-0.912
04	-1.246	-0.222	-1.751	1.007
05	-1.467	-0.089	-0.78	0.874
06	-1.751	-1.065	-2.148	1.213
07	-2.819	1.143	-1.467	-0.558
08	-1.065	0.538	-0.558	0.315
09	1.325	-2.819	-2.148	-2.819
10	-0.558	-2.148	1.179	-2.819
11	-1.467	-0.912	1.196	-2.819
12	1.247	-2.148	-1.246	-2.148
13	1.179	-2.819	-1.246	-0.912

Standard thresholds

P-value	Threshold
0.001	4.55396
0.0005	5.39746
0.0001	7.15913