BCL6.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	BCL6.H12INVIVO.0.PSM.A
Gene (human)	BCL6 (GeneCards)
Gene synonyms (human)	BCL5, LAZ3, ZBTB27, ZNF51
Gene (mouse)	Bcl6
Gene synonyms (mouse)	Bcl-6
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	16
Consensus	nhGCTTTCKAGGAAYn
GC content	44.37%
Information content (bits; total / per base)	20.273 / 1.267
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	7198

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	10 (67)	0.794	0.933	0.745	0.928	0.762	0.931	3.026	5.63	116.824	680.959
Mouse	15 (93)	0.816	0.97	0.745	0.929	0.801	0.964	3.076	4.837	101.585	213.244

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	1.0	1.0	0.973	0.974	0.82	0.847
Overall, 2 experiments	best	1.0	1.0	0.998	0.998	0.896	0.908
Methyl HT-SELEX, 1 experiments	median	1.0	1.0	0.998	0.998	0.896	0.908
Methyl HT-SELEX, 1 experiments	best	1.0	1.0	0.998	0.998	0.896	0.908
Non-Methyl HT-SELEX, 1 experiments	median	1.0	1.0	0.948	0.949	0.743	0.785
Non-Methyl HT-SELEX, 1 experiments	best	1.0	1.0	0.948	0.949	0.743	0.785

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	10.132	3.449	0.406	0.257

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	BCL6 {2.3.3.22} (TFClass)
TFClass ID	TFClass: 2.3.3.22.2
HGNC	HGNC:1001
MGI	MGI:107187
EntrezGene (human)	GeneID:604 (SSTAR profile)
EntrezGene (mouse)	GeneID:12053 (SSTAR profile)
UniProt ID (human)	BCL6_HUMAN
UniProt ID (mouse)	BCL6_MOUSE
UniProt AC (human)	P41182 (TFClass)
UniProt AC (mouse)	P41183 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	10 human, 15 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	BCL6.H12INVIVO.0.PSM.A.pcm
PWM	BCL6.H12INVIVO.0.PSM.A.pwm
PFM	BCL6.H12INVIVO.0.PSM.A.pfm
Alignment	BCL6.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	BCL6.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	BCL6.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	BCL6.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	BCL6.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	BCL6.H12INVIVO.0.PSM.A_homer_format_0.001.txt BCL6.H12INVIVO.0.PSM.A_homer_format_0.0005.txt BCL6.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2234.5	1536.5	1739.5	1687.5
02	913.25	2029.25	790.25	3465.25
03	850.0	142.0	5814.0	392.0
04	116.0	6848.0	82.0	152.0
05	383.0	103.0	37.0	6675.0
06	269.0	376.0	277.0	6276.0
07	4.0	2.0	1.0	7191.0
08	0.0	7189.0	0.0	9.0
09	18.0	381.0	4399.0	2400.0
10	7168.0	7.0	7.0	16.0
11	54.0	1.0	7137.0	6.0
12	9.0	11.0	7149.0	29.0
13	6900.0	30.0	173.0	95.0
14	6920.0	24.0	40.0	214.0
15	1359.0	1552.0	182.0	4105.0
16	1515.75	1347.75	1693.75	2640.75

PFM

	A	C	G	T
01	0.31	0.213	0.242	0.234
02	0.127	0.282	0.11	0.481
03	0.118	0.02	0.808	0.054
04	0.016	0.951	0.011	0.021
05	0.053	0.014	0.005	0.927
06	0.037	0.052	0.038	0.872
07	0.001	0.0	0.0	0.999
08	0.0	0.999	0.0	0.001
09	0.003	0.053	0.611	0.333
10	0.996	0.001	0.001	0.002
11	0.008	0.0	0.992	0.001
12	0.001	0.002	0.993	0.004
13	0.959	0.004	0.024	0.013
14	0.961	0.003	0.006	0.03
15	0.189	0.216	0.025	0.57
16	0.211	0.187	0.235	0.367

PWM

	A	C	G	T
01	0.216	-0.158	-0.034	-0.064
02	-0.677	0.12	-0.821	0.655
03	-0.749	-2.525	1.172	-1.52
04	-2.724	1.336	-3.063	-2.458
05	-1.543	-2.84	-3.827	1.31
06	-1.894	-1.561	-1.864	1.248
07	-5.669	-6.057	-6.327	1.384
08	-6.699	1.384	-6.699	-5.079
09	-4.49	-1.548	0.893	0.288
10	1.381	-5.275	-5.275	-4.594
11	-3.467	-6.327	1.377	-5.39
12	-5.079	-4.915	1.379	-4.055
13	1.343	-4.024	-2.33	-2.92
14	1.346	-4.23	-3.754	-2.12
15	-0.28	-0.148	-2.28	0.824
16	-0.171	-0.289	-0.06	0.383

Standard thresholds

P-value	Threshold
0.001	-2.03654
0.0005	-0.26699
0.0001	3.44896