BACH2.H12RSNP.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	BACH2.H12RSNP.1.SM.B
Gene (human)	BACH2 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Bach2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	18
Consensus	dbSATGAGTCATGbTTWn
GC content	41.47%
Information content (bits; total / per base)	22.745 / 1.264
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	1869

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	5 (33)	0.521	0.545	0.387	0.431	0.688	0.736	1.977	2.226	50.244	70.161
Mouse	4 (25)	0.527	0.552	0.398	0.444	0.708	0.745	2.058	2.322	77.292	105.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	1.0	0.999	0.953	0.957	0.827	0.85
Overall, 2 experiments	best	1.0	1.0	1.0	1.0	0.932	0.941
Methyl HT-SELEX, 1 experiments	median	0.999	0.999	0.907	0.914	0.723	0.76
Methyl HT-SELEX, 1 experiments	best	0.999	0.999	0.907	0.914	0.723	0.76
Non-Methyl HT-SELEX, 1 experiments	median	1.0	1.0	1.0	1.0	0.932	0.941
Non-Methyl HT-SELEX, 1 experiments	best	1.0	1.0	1.0	1.0	0.932	0.941

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.98	0.916	0.884	0.848

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Jun-related {1.1.1} (TFClass)
TF subfamily	NFE2 {1.1.1.2} (TFClass)
TFClass ID	TFClass: 1.1.1.2.6
HGNC	HGNC:14078
MGI	MGI:894679
EntrezGene (human)	GeneID:60468 (SSTAR profile)
EntrezGene (mouse)	GeneID:12014 (SSTAR profile)
UniProt ID (human)	BACH2_HUMAN
UniProt ID (mouse)	BACH2_MOUSE
UniProt AC (human)	Q9BYV9 (TFClass)
UniProt AC (mouse)	P97303 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	5 human, 4 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	BACH2.H12RSNP.1.SM.B.pcm
PWM	BACH2.H12RSNP.1.SM.B.pwm
PFM	BACH2.H12RSNP.1.SM.B.pfm
Alignment	BACH2.H12RSNP.1.SM.B.words.tsv
Threshold to P-value map	BACH2.H12RSNP.1.SM.B.thr
Motif in other formats
JASPAR format	BACH2.H12RSNP.1.SM.B_jaspar_format.txt
MEME format	BACH2.H12RSNP.1.SM.B_meme_format.meme
Transfac format	BACH2.H12RSNP.1.SM.B_transfac_format.txt
Homer format	BACH2.H12RSNP.1.SM.B_homer_format_0.001.txt BACH2.H12RSNP.1.SM.B_homer_format_0.0005.txt BACH2.H12RSNP.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1043.0	201.0	371.0	254.0
02	155.0	524.0	664.0	526.0
03	54.0	1337.0	420.0	58.0
04	1781.0	0.0	88.0	0.0
05	0.0	0.0	0.0	1869.0
06	0.0	0.0	1869.0	0.0
07	1869.0	0.0	0.0	0.0
08	0.0	751.0	1118.0	0.0
09	0.0	0.0	0.0	1869.0
10	0.0	1869.0	0.0	0.0
11	1869.0	0.0	0.0	0.0
12	0.0	67.0	0.0	1802.0
13	13.0	149.0	1689.0	18.0
14	209.0	675.0	731.0	254.0
15	11.0	62.0	36.0	1760.0
16	355.0	11.0	21.0	1482.0
17	487.25	143.25	166.25	1072.25
18	377.5	461.5	528.5	501.5

PFM

	A	C	G	T
01	0.558	0.108	0.199	0.136
02	0.083	0.28	0.355	0.281
03	0.029	0.715	0.225	0.031
04	0.953	0.0	0.047	0.0
05	0.0	0.0	0.0	1.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.402	0.598	0.0
09	0.0	0.0	0.0	1.0
10	0.0	1.0	0.0	0.0
11	1.0	0.0	0.0	0.0
12	0.0	0.036	0.0	0.964
13	0.007	0.08	0.904	0.01
14	0.112	0.361	0.391	0.136
15	0.006	0.033	0.019	0.942
16	0.19	0.006	0.011	0.793
17	0.261	0.077	0.089	0.574
18	0.202	0.247	0.283	0.268

PWM

	A	C	G	T
01	0.801	-0.838	-0.23	-0.606
02	-1.095	0.114	0.35	0.118
03	-2.128	1.049	-0.106	-2.058
04	1.335	-5.518	-1.652	-5.518
05	-5.518	-5.518	-5.518	1.383
06	-5.518	-5.518	1.383	-5.518
07	1.383	-5.518	-5.518	-5.518
08	-5.518	0.473	0.87	-5.518
09	-5.518	-5.518	-5.518	1.383
10	-5.518	1.383	-5.518	-5.518
11	1.383	-5.518	-5.518	-5.518
12	-5.518	-1.918	-5.518	1.347
13	-3.451	-1.134	1.282	-3.161
14	-0.8	0.367	0.446	-0.606
15	-3.595	-1.994	-2.516	1.323
16	-0.273	-3.595	-3.02	1.152
17	0.042	-1.173	-1.026	0.828
18	-0.212	-0.012	0.123	0.07

Standard thresholds

P-value	Threshold
0.001	-5.35834
0.0005	-3.31009
0.0001	1.02321