ATOH1.H12CORE.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ATOH1.H12CORE.0.P.B
Gene (human)	ATOH1 (GeneCards)
Gene synonyms (human)	ATH1, BHLHA14
Gene (mouse)	Atoh1
Gene synonyms (mouse)	Ath1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	10
Consensus	RRCAGMTGKb
GC content	58.67%
Information content (bits; total / per base)	12.361 / 1.236
Data sources	ChIP-Seq
Aligned words	1001

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (14)	0.93	0.941	0.847	0.859	0.896	0.909	2.817	2.969	154.667	289.854
Mouse	2 (14)	0.814	0.953	0.681	0.89	0.777	0.922	2.222	3.192	89.577	477.301

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.83	0.798	0.78	0.763	0.757	0.743
Overall, 4 experiments	best	0.984	0.969	0.976	0.959	0.974	0.955
Methyl HT-SELEX, 1 experiments	median	0.984	0.969	0.976	0.959	0.974	0.955
Methyl HT-SELEX, 1 experiments	best	0.984	0.969	0.976	0.959	0.974	0.955
Non-Methyl HT-SELEX, 3 experiments	median	0.685	0.649	0.595	0.587	0.554	0.554
Non-Methyl HT-SELEX, 3 experiments	best	0.974	0.948	0.965	0.94	0.961	0.933

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.929	0.837	0.907	0.62
batch 2	0.929	0.855	0.895	0.643

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Tal-related {1.2.3} (TFClass)
TF subfamily	Neurogenin-ATO {1.2.3.4} (TFClass)
TFClass ID	TFClass: 1.2.3.4.8
HGNC	HGNC:797
MGI	MGI:104654
EntrezGene (human)	GeneID:474 (SSTAR profile)
EntrezGene (mouse)	GeneID:11921 (SSTAR profile)
UniProt ID (human)	ATOH1_HUMAN
UniProt ID (mouse)	ATOH1_MOUSE
UniProt AC (human)	Q92858 (TFClass)
UniProt AC (mouse)	P48985 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 2 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	ATOH1.H12CORE.0.P.B.pcm
PWM	ATOH1.H12CORE.0.P.B.pwm
PFM	ATOH1.H12CORE.0.P.B.pfm
Alignment	ATOH1.H12CORE.0.P.B.words.tsv
Threshold to P-value map	ATOH1.H12CORE.0.P.B.thr
Motif in other formats
JASPAR format	ATOH1.H12CORE.0.P.B_jaspar_format.txt
MEME format	ATOH1.H12CORE.0.P.B_meme_format.meme
Transfac format	ATOH1.H12CORE.0.P.B_transfac_format.txt
Homer format	ATOH1.H12CORE.0.P.B_homer_format_0.001.txt ATOH1.H12CORE.0.P.B_homer_format_0.0005.txt ATOH1.H12CORE.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	646.0	12.0	325.0	18.0
02	385.0	110.0	505.0	1.0
03	0.0	1001.0	0.0	0.0
04	1000.0	0.0	0.0	1.0
05	2.0	4.0	941.0	54.0
06	417.0	453.0	130.0	1.0
07	9.0	0.0	0.0	992.0
08	0.0	0.0	999.0	2.0
09	2.0	139.0	616.0	244.0
10	117.0	386.0	252.0	246.0

PFM

	A	C	G	T
01	0.645	0.012	0.325	0.018
02	0.385	0.11	0.504	0.001
03	0.0	1.0	0.0	0.0
04	0.999	0.0	0.0	0.001
05	0.002	0.004	0.94	0.054
06	0.417	0.453	0.13	0.001
07	0.009	0.0	0.0	0.991
08	0.0	0.0	0.998	0.002
09	0.002	0.139	0.615	0.244
10	0.117	0.386	0.252	0.246

PWM

	A	C	G	T
01	0.944	-2.91	0.26	-2.547
02	0.428	-0.813	0.699	-4.526
03	-4.983	1.381	-4.983	-4.983
04	1.38	-4.983	-4.983	-4.526
05	-4.214	-3.784	1.319	-1.509
06	0.508	0.59	-0.649	-4.526
07	-3.157	-4.983	-4.983	1.372
08	-4.983	-4.983	1.379	-4.214
09	-4.214	-0.583	0.897	-0.025
10	-0.753	0.431	0.007	-0.017

Standard thresholds

P-value	Threshold
0.001	3.325115
0.0005	4.50704
0.0001	7.7636