MotifATF4.H12INVIVO.0.P.B
Gene (human)ATF4
(GeneCards)
Gene synonyms (human)CREB2, TXREB
Gene (mouse)Atf4
Gene synonyms (mouse)Creb2
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
B
Motif length13
ConsensusdvMTGATGCAAYh
GC content41.35%
Information content (bits; total / per base)15.967 / 1.228
Data sourcesChIP-Seq
Aligned words1000

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 7 (42) 0.983 0.994 0.972 0.987 0.981 0.995 5.804 6.915 775.757 1046.222
Mouse 2 (9) 0.95 0.985 0.933 0.978 0.922 0.978 4.345 5.137 537.409 726.244

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.752 0.716 0.647 0.63 0.578 0.58
best 0.92 0.834 0.925 0.853 0.952 0.881
Methyl HT-SELEX, 1 experiments median 0.92 0.834 0.92 0.853 0.83 0.791
best 0.92 0.834 0.92 0.853 0.83 0.791
Non-Methyl HT-SELEX, 5 experiments median 0.727 0.697 0.612 0.626 0.561 0.575
best 0.868 0.766 0.925 0.834 0.952 0.881

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 14.974 10.33 0.314 0.258
TF superclassBasic domains {1} (TFClass)
TF classBasic leucine zipper factors (bZIP) {1.1} (TFClass)
TF familyATF4-related {1.1.6} (TFClass)
TF subfamily {1.1.6.0} (TFClass)
TFClass IDTFClass: 1.1.6.0.1
HGNCHGNC:786
MGIMGI:88096
EntrezGene (human)GeneID:468
(SSTAR profile)
EntrezGene (mouse)GeneID:11911
(SSTAR profile)
UniProt ID (human)ATF4_HUMAN
UniProt ID (mouse)ATF4_MOUSE
UniProt AC (human)P18848
(TFClass)
UniProt AC (mouse)Q06507
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 7 human, 2 mouse
HT-SELEX 5
Methyl-HT-SELEX 1
PCM
ACGT
01361.094.0422.0123.0
02241.0146.0490.0123.0
03575.0301.0122.02.0
044.03.00.0993.0
052.09.0982.07.0
06976.05.010.09.0
073.069.012.0916.0
082.05.0992.01.0
09108.0817.00.075.0
10993.05.00.02.0
11997.01.02.00.0
1216.0298.093.0593.0
13373.0377.0120.0130.0
PFM
ACGT
010.3610.0940.4220.123
020.2410.1460.490.123
030.5750.3010.1220.002
040.0040.0030.00.993
050.0020.0090.9820.007
060.9760.0050.010.009
070.0030.0690.0120.916
080.0020.0050.9920.001
090.1080.8170.00.075
100.9930.0050.00.002
110.9970.0010.0020.0
120.0160.2980.0930.593
130.3730.3770.120.13
PWM
ACGT
010.365-0.9670.521-0.702
02-0.036-0.5330.67-0.702
030.8290.184-0.71-4.213
04-3.783-3.975-4.9821.374
05-4.213-3.1561.363-3.362
061.357-3.622-3.066-3.156
07-3.975-1.27-2.9091.294
08-4.213-3.6221.373-4.525
09-0.831.179-4.982-1.188
101.374-3.622-4.982-4.213
111.378-4.525-4.213-4.982
12-2.6530.175-0.9770.86
130.3980.408-0.727-0.648
Standard thresholds
P-value Threshold
0.001 1.57691
0.0005 3.04841
0.0001 5.99698