ATF3.H12INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ATF3.H12INVITRO.0.P.B
Gene (human)	ATF3 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Atf3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	10
Consensus	nvRTGACTCA
GC content	47.45%
Information content (bits; total / per base)	12.137 / 1.214
Data sources	ChIP-Seq
Aligned words	901

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	18 (118)	0.724	0.914	0.642	0.866	0.71	0.905	2.265	3.728	85.372	311.469
Mouse	13 (85)	0.872	0.913	0.8	0.853	0.853	0.9	3.068	3.592	173.167	246.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.93	0.902	0.903	0.861	0.869	0.821
Overall, 4 experiments	best	0.992	0.987	0.961	0.951	0.905	0.886
Methyl HT-SELEX, 2 experiments	median	0.969	0.957	0.931	0.909	0.883	0.852
Methyl HT-SELEX, 2 experiments	best	0.992	0.987	0.961	0.951	0.905	0.886
Non-Methyl HT-SELEX, 2 experiments	median	0.903	0.866	0.899	0.845	0.869	0.815
Non-Methyl HT-SELEX, 2 experiments	best	0.914	0.877	0.905	0.854	0.876	0.824

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.018	2.443	0.055	0.09

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.731	0.349	0.609	0.382
batch 2	0.693	0.377	0.484	0.372

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Fos-related {1.1.2} (TFClass)
TF subfamily	ATF3-like {1.1.2.2} (TFClass)
TFClass ID	TFClass: 1.1.2.2.1
HGNC	HGNC:785
MGI	MGI:109384
EntrezGene (human)	GeneID:467 (SSTAR profile)
EntrezGene (mouse)	GeneID:11910 (SSTAR profile)
UniProt ID (human)	ATF3_HUMAN
UniProt ID (mouse)	ATF3_MOUSE
UniProt AC (human)	P18847 (TFClass)
UniProt AC (mouse)	Q60765 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	18 human, 13 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	ATF3.H12INVITRO.0.P.B.pcm
PWM	ATF3.H12INVITRO.0.P.B.pwm
PFM	ATF3.H12INVITRO.0.P.B.pfm
Alignment	ATF3.H12INVITRO.0.P.B.words.tsv
Threshold to P-value map	ATF3.H12INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	ATF3.H12INVITRO.0.P.B_jaspar_format.txt
MEME format	ATF3.H12INVITRO.0.P.B_meme_format.meme
Transfac format	ATF3.H12INVITRO.0.P.B_transfac_format.txt
Homer format	ATF3.H12INVITRO.0.P.B_homer_format_0.001.txt ATF3.H12INVITRO.0.P.B_homer_format_0.0005.txt ATF3.H12INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	166.0	198.0	296.0	241.0
02	150.0	156.0	488.0	107.0
03	403.0	163.0	325.0	10.0
04	2.0	2.0	1.0	896.0
05	1.0	7.0	883.0	10.0
06	890.0	1.0	3.0	7.0
07	0.0	757.0	5.0	139.0
08	11.0	1.0	152.0	737.0
09	61.0	806.0	3.0	31.0
10	870.0	23.0	5.0	3.0

PFM

	A	C	G	T
01	0.184	0.22	0.329	0.267
02	0.166	0.173	0.542	0.119
03	0.447	0.181	0.361	0.011
04	0.002	0.002	0.001	0.994
05	0.001	0.008	0.98	0.011
06	0.988	0.001	0.003	0.008
07	0.0	0.84	0.006	0.154
08	0.012	0.001	0.169	0.818
09	0.068	0.895	0.003	0.034
10	0.966	0.026	0.006	0.003

PWM

	A	C	G	T
01	-0.303	-0.128	0.271	0.067
02	-0.403	-0.364	0.769	-0.736
03	0.578	-0.321	0.364	-2.965
04	-4.116	-4.116	-4.431	1.375
05	-4.431	-3.261	1.361	-2.965
06	1.368	-4.431	-3.877	-3.261
07	-4.894	1.207	-3.522	-0.478
08	-2.883	-4.431	-0.39	1.18
09	-1.286	1.269	-3.877	-1.937
10	1.346	-2.218	-3.522	-3.877

Standard thresholds

P-value	Threshold
0.001	3.894585
0.0005	4.92345
0.0001	7.441915