ATF3.H12CORE.3.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ATF3.H12CORE.3.SM.B
Gene (human)	ATF3 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Atf3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	3
Quality	B

Motif length	15
Consensus	nvbKATGACGTCAYn
GC content	46.64%
Information content (bits; total / per base)	17.147 / 1.143
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	2272

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	18 (118)	0.654	0.86	0.541	0.788	0.592	0.835	1.815	4.065	65.909	392.538
Mouse	13 (85)	0.744	0.775	0.607	0.69	0.698	0.727	2.11	2.835	64.319	99.585

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	1.0	1.0	1.0	1.0	0.999	0.999
Overall, 4 experiments	best	1.0	1.0	1.0	1.0	1.0	0.999
Methyl HT-SELEX, 2 experiments	median	1.0	1.0	1.0	0.999	0.999	0.998
Methyl HT-SELEX, 2 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999
Non-Methyl HT-SELEX, 2 experiments	median	1.0	1.0	1.0	1.0	1.0	0.999
Non-Methyl HT-SELEX, 2 experiments	best	1.0	1.0	1.0	1.0	1.0	0.999

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	4.829	8.629	0.135	0.129

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.831	0.517	0.737	0.482
batch 2	0.868	0.694	0.835	0.65

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Fos-related {1.1.2} (TFClass)
TF subfamily	ATF3-like {1.1.2.2} (TFClass)
TFClass ID	TFClass: 1.1.2.2.1
HGNC	HGNC:785
MGI	MGI:109384
EntrezGene (human)	GeneID:467 (SSTAR profile)
EntrezGene (mouse)	GeneID:11910 (SSTAR profile)
UniProt ID (human)	ATF3_HUMAN
UniProt ID (mouse)	ATF3_MOUSE
UniProt AC (human)	P18847 (TFClass)
UniProt AC (mouse)	Q60765 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	18 human, 13 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	ATF3.H12CORE.3.SM.B.pcm
PWM	ATF3.H12CORE.3.SM.B.pwm
PFM	ATF3.H12CORE.3.SM.B.pfm
Alignment	ATF3.H12CORE.3.SM.B.words.tsv
Threshold to P-value map	ATF3.H12CORE.3.SM.B.thr
Motif in other formats
JASPAR format	ATF3.H12CORE.3.SM.B_jaspar_format.txt
MEME format	ATF3.H12CORE.3.SM.B_meme_format.meme
Transfac format	ATF3.H12CORE.3.SM.B_transfac_format.txt
Homer format	ATF3.H12CORE.3.SM.B_homer_format_0.001.txt ATF3.H12CORE.3.SM.B_homer_format_0.0005.txt ATF3.H12CORE.3.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	669.5	550.5	675.5	376.5
02	799.5	474.5	776.5	221.5
03	192.0	566.0	291.0	1223.0
04	211.0	73.0	1725.0	263.0
05	1923.0	28.0	321.0	0.0
06	0.0	6.0	2.0	2264.0
07	0.0	0.0	2247.0	25.0
08	2272.0	0.0	0.0	0.0
09	0.0	1999.0	2.0	271.0
10	376.0	15.0	1879.0	2.0
11	3.0	5.0	1.0	2263.0
12	250.0	1998.0	13.0	11.0
13	2217.0	11.0	34.0	10.0
14	31.75	769.75	204.75	1265.75
15	418.75	807.75	419.75	625.75

PFM

	A	C	G	T
01	0.295	0.242	0.297	0.166
02	0.352	0.209	0.342	0.097
03	0.085	0.249	0.128	0.538
04	0.093	0.032	0.759	0.116
05	0.846	0.012	0.141	0.0
06	0.0	0.003	0.001	0.996
07	0.0	0.0	0.989	0.011
08	1.0	0.0	0.0	0.0
09	0.0	0.88	0.001	0.119
10	0.165	0.007	0.827	0.001
11	0.001	0.002	0.0	0.996
12	0.11	0.879	0.006	0.005
13	0.976	0.005	0.015	0.004
14	0.014	0.339	0.09	0.557
15	0.184	0.356	0.185	0.275

PWM

	A	C	G	T
01	0.164	-0.031	0.173	-0.409
02	0.341	-0.179	0.312	-0.936
03	-1.078	-0.004	-0.666	0.765
04	-0.985	-2.029	1.109	-0.766
05	1.217	-2.947	-0.568	-5.687
06	-5.687	-4.275	-4.976	1.38
07	-5.687	-5.687	1.373	-3.052
08	1.384	-5.687	-5.687	-5.687
09	-5.687	1.256	-4.976	-0.736
10	-0.411	-3.516	1.194	-4.976
11	-4.75	-4.409	-5.27	1.38
12	-0.816	1.255	-3.642	-3.786
13	1.359	-3.786	-2.764	-3.866
14	-2.829	0.303	-1.014	0.799
15	-0.304	0.351	-0.301	0.097

Standard thresholds

P-value	Threshold
0.001	0.31996
0.0005	1.94946
0.0001	5.28406