ATF3.H12CORE.2.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ATF3.H12CORE.2.P.B
Gene (human)	ATF3 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Atf3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	12
Consensus	RRTGAYGYAAYh
GC content	45.8%
Information content (bits; total / per base)	13.78 / 1.148
Data sources	ChIP-Seq
Aligned words	772

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	18 (118)	0.736	0.965	0.677	0.926	0.733	0.959	2.555	5.192	136.157	693.854
Mouse	13 (85)	0.852	0.876	0.718	0.769	0.813	0.844	2.495	2.85	125.678	225.149

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.999	0.999	0.999	0.998	0.998	0.997
Overall, 4 experiments	best	1.0	0.999	0.999	0.999	0.999	0.998
Methyl HT-SELEX, 2 experiments	median	0.999	0.998	0.999	0.998	0.996	0.994
Methyl HT-SELEX, 2 experiments	best	0.999	0.999	0.999	0.999	0.997	0.997
Non-Methyl HT-SELEX, 2 experiments	median	0.999	0.999	0.999	0.998	0.999	0.998
Non-Methyl HT-SELEX, 2 experiments	best	1.0	0.999	0.999	0.999	0.999	0.998

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	4.616	8.332	0.133	0.136

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.722	0.428	0.767	0.518
batch 2	0.824	0.654	0.739	0.549

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Fos-related {1.1.2} (TFClass)
TF subfamily	ATF3-like {1.1.2.2} (TFClass)
TFClass ID	TFClass: 1.1.2.2.1
HGNC	HGNC:785
MGI	MGI:109384
EntrezGene (human)	GeneID:467 (SSTAR profile)
EntrezGene (mouse)	GeneID:11910 (SSTAR profile)
UniProt ID (human)	ATF3_HUMAN
UniProt ID (mouse)	ATF3_MOUSE
UniProt AC (human)	P18847 (TFClass)
UniProt AC (mouse)	Q60765 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	18 human, 13 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	ATF3.H12CORE.2.P.B.pcm
PWM	ATF3.H12CORE.2.P.B.pwm
PFM	ATF3.H12CORE.2.P.B.pfm
Alignment	ATF3.H12CORE.2.P.B.words.tsv
Threshold to P-value map	ATF3.H12CORE.2.P.B.thr
Motif in other formats
JASPAR format	ATF3.H12CORE.2.P.B_jaspar_format.txt
MEME format	ATF3.H12CORE.2.P.B_meme_format.meme
Transfac format	ATF3.H12CORE.2.P.B_transfac_format.txt
Homer format	ATF3.H12CORE.2.P.B_homer_format_0.001.txt ATF3.H12CORE.2.P.B_homer_format_0.0005.txt ATF3.H12CORE.2.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	133.0	50.0	563.0	26.0
02	534.0	37.0	200.0	1.0
03	0.0	0.0	0.0	772.0
04	0.0	1.0	771.0	0.0
05	772.0	0.0	0.0	0.0
06	1.0	400.0	8.0	363.0
07	1.0	2.0	660.0	109.0
08	43.0	392.0	0.0	337.0
09	497.0	274.0	0.0	1.0
10	688.0	30.0	10.0	44.0
11	9.0	322.0	90.0	351.0
12	200.0	321.0	112.0	139.0

PFM

	A	C	G	T
01	0.172	0.065	0.729	0.034
02	0.692	0.048	0.259	0.001
03	0.0	0.0	0.0	1.0
04	0.0	0.001	0.999	0.0
05	1.0	0.0	0.0	0.0
06	0.001	0.518	0.01	0.47
07	0.001	0.003	0.855	0.141
08	0.056	0.508	0.0	0.437
09	0.644	0.355	0.0	0.001
10	0.891	0.039	0.013	0.057
11	0.012	0.417	0.117	0.455
12	0.259	0.416	0.145	0.18

PWM

	A	C	G	T
01	-0.368	-1.327	1.065	-1.951
02	1.012	-1.616	0.035	-4.292
03	-4.763	-4.763	-4.763	1.38
04	-4.763	-4.292	1.379	-4.763
05	1.38	-4.763	-4.763	-4.763
06	-4.292	0.724	-3.003	0.628
07	-4.292	-3.973	1.223	-0.565
08	-1.472	0.704	-4.763	0.554
09	0.941	0.348	-4.763	-4.292
10	1.265	-1.816	-2.815	-1.45
11	-2.905	0.508	-0.753	0.594
12	0.035	0.505	-0.538	-0.325

Standard thresholds

P-value	Threshold
0.001	2.93537
0.0005	4.272805
0.0001	6.99411