ATF2.H12RSNP.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ATF2.H12RSNP.0.PSM.A
Gene (human)	ATF2 (GeneCards)
Gene synonyms (human)	CREB2, CREBP1
Gene (mouse)	Atf2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	12
Consensus	vRTGACGTAAKb
GC content	46.52%
Information content (bits; total / per base)	16.307 / 1.359
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	1464

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	5 (35)	0.956	0.993	0.944	0.987	0.989	0.997	6.229	7.101	800.06	1226.638
Mouse	2 (12)	0.682	0.74	0.632	0.718	0.778	0.855	3.008	3.837	215.654	298.086

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.98	0.967	0.945	0.926	0.852	0.838
Overall, 4 experiments	best	0.994	0.991	0.987	0.981	0.925	0.917
Methyl HT-SELEX, 2 experiments	median	0.988	0.981	0.968	0.957	0.891	0.881
Methyl HT-SELEX, 2 experiments	best	0.994	0.991	0.987	0.981	0.925	0.917
Non-Methyl HT-SELEX, 2 experiments	median	0.967	0.947	0.928	0.902	0.836	0.817
Non-Methyl HT-SELEX, 2 experiments	best	0.977	0.963	0.941	0.92	0.846	0.831

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	17.807	47.673	0.421	0.386

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.992	0.911	0.95	0.581
batch 2	0.915	0.864	0.901	0.695

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Jun-related {1.1.1} (TFClass)
TF subfamily	ATF2 {1.1.1.3} (TFClass)
TFClass ID	TFClass: 1.1.1.3.1
HGNC	HGNC:784
MGI	MGI:109349
EntrezGene (human)	GeneID:1386 (SSTAR profile)
EntrezGene (mouse)	GeneID:11909 (SSTAR profile)
UniProt ID (human)	ATF2_HUMAN
UniProt ID (mouse)	ATF2_MOUSE
UniProt AC (human)	P15336 (TFClass)
UniProt AC (mouse)	P16951 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	5 human, 2 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	ATF2.H12RSNP.0.PSM.A.pcm
PWM	ATF2.H12RSNP.0.PSM.A.pwm
PFM	ATF2.H12RSNP.0.PSM.A.pfm
Alignment	ATF2.H12RSNP.0.PSM.A.words.tsv
Threshold to P-value map	ATF2.H12RSNP.0.PSM.A.thr
Motif in other formats
JASPAR format	ATF2.H12RSNP.0.PSM.A_jaspar_format.txt
MEME format	ATF2.H12RSNP.0.PSM.A_meme_format.meme
Transfac format	ATF2.H12RSNP.0.PSM.A_transfac_format.txt
Homer format	ATF2.H12RSNP.0.PSM.A_homer_format_0.001.txt ATF2.H12RSNP.0.PSM.A_homer_format_0.0005.txt ATF2.H12RSNP.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	313.75	284.75	659.75	205.75
02	743.75	41.75	649.75	28.75
03	0.0	0.0	0.0	1464.0
04	0.0	0.0	1456.0	8.0
05	1464.0	0.0	0.0	0.0
06	0.0	1460.0	0.0	4.0
07	0.0	0.0	1464.0	0.0
08	0.0	0.0	0.0	1464.0
09	794.0	670.0	0.0	0.0
10	1460.0	0.0	4.0	0.0
11	92.25	226.25	281.25	864.25
12	222.75	383.75	590.75	266.75

PFM

	A	C	G	T
01	0.214	0.195	0.451	0.141
02	0.508	0.029	0.444	0.02
03	0.0	0.0	0.0	1.0
04	0.0	0.0	0.995	0.005
05	1.0	0.0	0.0	0.0
06	0.0	0.997	0.0	0.003
07	0.0	0.0	1.0	0.0
08	0.0	0.0	0.0	1.0
09	0.542	0.458	0.0	0.0
10	0.997	0.0	0.003	0.0
11	0.063	0.155	0.192	0.59
12	0.152	0.262	0.404	0.182

PWM

	A	C	G	T
01	-0.153	-0.25	0.587	-0.572
02	0.707	-2.133	0.572	-2.488
03	-5.308	-5.308	-5.308	1.383
04	-5.308	-5.308	1.377	-3.623
05	1.383	-5.308	-5.308	-5.308
06	-5.308	1.38	-5.308	-4.146
07	-5.308	-5.308	1.383	-5.308
08	-5.308	-5.308	-5.308	1.383
09	0.772	0.602	-5.308	-5.308
10	1.38	-5.308	-4.146	-5.308
11	-1.364	-0.478	-0.262	0.856
12	-0.493	0.047	0.477	-0.314

Standard thresholds

P-value	Threshold
0.001	-0.82407
0.0005	1.36632
0.0001	4.962785