ATF2.H12INVIVO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ATF2.H12INVIVO.1.P.B
Gene (human)	ATF2 (GeneCards)
Gene synonyms (human)	CREB2, CREBP1
Gene (mouse)	Atf2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	12
Consensus	dATGAYGTCATn
GC content	37.43%
Information content (bits; total / per base)	15.6 / 1.3
Data sources	ChIP-Seq
Aligned words	976

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	5 (35)	0.978	0.995	0.929	0.978	0.989	0.998	6.042	7.19	799.036	1208.638
Mouse	2 (12)	0.818	0.884	0.743	0.827	0.802	0.866	3.229	3.708	202.244	257.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.971	0.955	0.929	0.906	0.835	0.818
Overall, 4 experiments	best	0.997	0.995	0.989	0.984	0.93	0.925
Methyl HT-SELEX, 2 experiments	median	0.99	0.984	0.969	0.959	0.893	0.884
Methyl HT-SELEX, 2 experiments	best	0.997	0.995	0.989	0.984	0.93	0.925
Non-Methyl HT-SELEX, 2 experiments	median	0.944	0.914	0.892	0.857	0.8	0.775
Non-Methyl HT-SELEX, 2 experiments	best	0.959	0.936	0.908	0.879	0.813	0.792

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.826	10.46	0.216	0.23

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.754	0.394	0.667	0.435
batch 2	0.816	0.628	0.728	0.526

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Jun-related {1.1.1} (TFClass)
TF subfamily	ATF2 {1.1.1.3} (TFClass)
TFClass ID	TFClass: 1.1.1.3.1
HGNC	HGNC:784
MGI	MGI:109349
EntrezGene (human)	GeneID:1386 (SSTAR profile)
EntrezGene (mouse)	GeneID:11909 (SSTAR profile)
UniProt ID (human)	ATF2_HUMAN
UniProt ID (mouse)	ATF2_MOUSE
UniProt AC (human)	P15336 (TFClass)
UniProt AC (mouse)	P16951 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	5 human, 2 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	ATF2.H12INVIVO.1.P.B.pcm
PWM	ATF2.H12INVIVO.1.P.B.pwm
PFM	ATF2.H12INVIVO.1.P.B.pfm
Alignment	ATF2.H12INVIVO.1.P.B.words.tsv
Threshold to P-value map	ATF2.H12INVIVO.1.P.B.thr
Motif in other formats
JASPAR format	ATF2.H12INVIVO.1.P.B_jaspar_format.txt
MEME format	ATF2.H12INVIVO.1.P.B_meme_format.meme
Transfac format	ATF2.H12INVIVO.1.P.B_transfac_format.txt
Homer format	ATF2.H12INVIVO.1.P.B_homer_format_0.001.txt ATF2.H12INVIVO.1.P.B_homer_format_0.0005.txt ATF2.H12INVIVO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	359.0	106.0	354.0	157.0
02	763.0	4.0	193.0	16.0
03	5.0	9.0	4.0	958.0
04	10.0	3.0	943.0	20.0
05	964.0	3.0	7.0	2.0
06	7.0	244.0	49.0	676.0
07	3.0	2.0	964.0	7.0
08	15.0	9.0	1.0	951.0
09	156.0	806.0	10.0	4.0
10	956.0	2.0	10.0	8.0
11	5.0	107.0	58.0	806.0
12	199.0	341.0	155.0	281.0

PFM

	A	C	G	T
01	0.368	0.109	0.363	0.161
02	0.782	0.004	0.198	0.016
03	0.005	0.009	0.004	0.982
04	0.01	0.003	0.966	0.02
05	0.988	0.003	0.007	0.002
06	0.007	0.25	0.05	0.693
07	0.003	0.002	0.988	0.007
08	0.015	0.009	0.001	0.974
09	0.16	0.826	0.01	0.004
10	0.98	0.002	0.01	0.008
11	0.005	0.11	0.059	0.826
12	0.204	0.349	0.159	0.288

PWM

	A	C	G	T
01	0.384	-0.825	0.37	-0.437
02	1.135	-3.76	-0.233	-2.629
03	-3.599	-3.132	-3.76	1.362
04	-3.043	-3.952	1.347	-2.426
05	1.369	-3.952	-3.338	-4.19
06	-3.338	0.0	-1.578	1.015
07	-3.952	-4.19	1.369	-3.338
08	-2.688	-3.132	-4.503	1.355
09	-0.443	1.19	-3.043	-3.76
10	1.36	-4.19	-3.043	-3.23
11	-3.599	-0.815	-1.415	1.19
12	-0.202	0.333	-0.45	0.14

Standard thresholds

P-value	Threshold
0.001	2.12321
0.0005	3.429715
0.0001	6.264195