ATF2.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ATF2.H12INVITRO.0.PSM.A
Gene (human)	ATF2 (GeneCards)
Gene synonyms (human)	CREB2, CREBP1
Gene (mouse)	Atf2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	nRTGACGTvRn
GC content	45.34%
Information content (bits; total / per base)	10.77 / 0.979
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9738

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	5 (35)	0.984	0.996	0.957	0.988	0.99	0.997	6.281	7.176	798.569	1220.367
Mouse	2 (12)	0.83	0.899	0.76	0.855	0.797	0.87	3.078	3.962	225.443	291.824

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.98	0.967	0.955	0.937	0.872	0.857
Overall, 4 experiments	best	0.995	0.993	0.988	0.982	0.938	0.93
Methyl HT-SELEX, 2 experiments	median	0.988	0.981	0.973	0.961	0.907	0.895
Methyl HT-SELEX, 2 experiments	best	0.995	0.993	0.988	0.982	0.938	0.93
Non-Methyl HT-SELEX, 2 experiments	median	0.969	0.949	0.942	0.917	0.859	0.839
Non-Methyl HT-SELEX, 2 experiments	best	0.978	0.964	0.953	0.933	0.869	0.853

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	8.431	33.568	0.388	0.365

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.951	0.567	0.912	0.582
batch 2	0.884	0.712	0.84	0.623

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Jun-related {1.1.1} (TFClass)
TF subfamily	ATF2 {1.1.1.3} (TFClass)
TFClass ID	TFClass: 1.1.1.3.1
HGNC	HGNC:784
MGI	MGI:109349
EntrezGene (human)	GeneID:1386 (SSTAR profile)
EntrezGene (mouse)	GeneID:11909 (SSTAR profile)
UniProt ID (human)	ATF2_HUMAN
UniProt ID (mouse)	ATF2_MOUSE
UniProt AC (human)	P15336 (TFClass)
UniProt AC (mouse)	P16951 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	5 human, 2 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	ATF2.H12INVITRO.0.PSM.A.pcm
PWM	ATF2.H12INVITRO.0.PSM.A.pwm
PFM	ATF2.H12INVITRO.0.PSM.A.pfm
Alignment	ATF2.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	ATF2.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	ATF2.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	ATF2.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	ATF2.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	ATF2.H12INVITRO.0.PSM.A_homer_format_0.001.txt ATF2.H12INVITRO.0.PSM.A_homer_format_0.0005.txt ATF2.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1896.5	2669.5	3652.5	1519.5
02	6685.25	461.25	2374.25	217.25
03	1.0	10.0	8.0	9719.0
04	0.0	0.0	7180.0	2558.0
05	9736.0	0.0	2.0	0.0
06	0.0	8857.0	128.0	753.0
07	1277.0	656.0	7775.0	30.0
08	363.0	918.0	96.0	8361.0
09	3595.0	4421.0	1101.0	621.0
10	6214.25	765.25	1915.25	843.25
11	1504.0	3199.0	2381.0	2654.0

PFM

	A	C	G	T
01	0.195	0.274	0.375	0.156
02	0.687	0.047	0.244	0.022
03	0.0	0.001	0.001	0.998
04	0.0	0.0	0.737	0.263
05	1.0	0.0	0.0	0.0
06	0.0	0.91	0.013	0.077
07	0.131	0.067	0.798	0.003
08	0.037	0.094	0.01	0.859
09	0.369	0.454	0.113	0.064
10	0.638	0.079	0.197	0.087
11	0.154	0.329	0.245	0.273

PWM

	A	C	G	T
01	-0.249	0.092	0.405	-0.471
02	1.01	-1.66	-0.025	-2.407
03	-6.606	-5.289	-5.467	1.384
04	-6.967	-6.967	1.081	0.049
05	1.385	-6.967	-6.341	-6.967
06	-6.967	1.291	-2.929	-1.171
07	-0.644	-1.309	1.161	-4.323
08	-1.898	-0.974	-3.21	1.233
09	0.389	0.596	-0.792	-1.363
10	0.937	-1.155	-0.24	-1.058
11	-0.481	0.273	-0.022	0.086

Standard thresholds

P-value	Threshold
0.001	4.61571
0.0005	5.62346
0.0001	7.48332