ASCL2.H12RSNP.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ASCL2.H12RSNP.0.PSM.A
Gene (human)	ASCL2 (GeneCards)
Gene synonyms (human)	BHLHA45, HASH2
Gene (mouse)	Ascl2
Gene synonyms (mouse)	Mash2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	nhRCAGCTGCYnhn
GC content	58.52%
Information content (bits; total / per base)	14.908 / 1.065
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	359

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	2 (12)	0.858	0.909	0.777	0.834	0.752	0.815	2.321	2.657	150.652	290.009

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.864	0.847	0.716	0.714	0.616	0.631
Overall, 6 experiments	best	0.963	0.947	0.868	0.85	0.731	0.736
Methyl HT-SELEX, 2 experiments	median	0.894	0.876	0.75	0.744	0.637	0.651
Methyl HT-SELEX, 2 experiments	best	0.902	0.881	0.766	0.755	0.649	0.66
Non-Methyl HT-SELEX, 4 experiments	median	0.748	0.742	0.636	0.641	0.574	0.585
Non-Methyl HT-SELEX, 4 experiments	best	0.963	0.947	0.868	0.85	0.731	0.736

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.706	0.429	0.717	0.512

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	MyoD-ASC-related {1.2.2} (TFClass)
TF subfamily	ASC {1.2.2.2} (TFClass)
TFClass ID	TFClass: 1.2.2.2.2
HGNC	HGNC:739
MGI	MGI:96920
EntrezGene (human)	GeneID:430 (SSTAR profile)
EntrezGene (mouse)	GeneID:17173 (SSTAR profile)
UniProt ID (human)	ASCL2_HUMAN
UniProt ID (mouse)	ASCL2_MOUSE
UniProt AC (human)	Q99929 (TFClass)
UniProt AC (mouse)	O35885 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 2 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	ASCL2.H12RSNP.0.PSM.A.pcm
PWM	ASCL2.H12RSNP.0.PSM.A.pwm
PFM	ASCL2.H12RSNP.0.PSM.A.pfm
Alignment	ASCL2.H12RSNP.0.PSM.A.words.tsv
Threshold to P-value map	ASCL2.H12RSNP.0.PSM.A.thr
Motif in other formats
JASPAR format	ASCL2.H12RSNP.0.PSM.A_jaspar_format.txt
MEME format	ASCL2.H12RSNP.0.PSM.A_meme_format.meme
Transfac format	ASCL2.H12RSNP.0.PSM.A_transfac_format.txt
Homer format	ASCL2.H12RSNP.0.PSM.A_homer_format_0.001.txt ASCL2.H12RSNP.0.PSM.A_homer_format_0.0005.txt ASCL2.H12RSNP.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	47.5	103.5	115.5	92.5
02	196.75	54.75	49.75	57.75
03	175.0	32.0	137.0	15.0
04	1.0	358.0	0.0	0.0
05	359.0	0.0	0.0	0.0
06	0.0	4.0	355.0	0.0
07	1.0	358.0	0.0	0.0
08	0.0	0.0	0.0	359.0
09	2.0	2.0	355.0	0.0
10	2.0	337.0	0.0	20.0
11	20.0	131.0	34.0	174.0
12	93.0	76.0	68.0	122.0
13	76.0	145.0	26.0	112.0
14	75.25	129.25	70.25	84.25

PFM

	A	C	G	T
01	0.132	0.288	0.322	0.258
02	0.548	0.153	0.139	0.161
03	0.487	0.089	0.382	0.042
04	0.003	0.997	0.0	0.0
05	1.0	0.0	0.0	0.0
06	0.0	0.011	0.989	0.0
07	0.003	0.997	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.006	0.006	0.989	0.0
10	0.006	0.939	0.0	0.056
11	0.056	0.365	0.095	0.485
12	0.259	0.212	0.189	0.34
13	0.212	0.404	0.072	0.312
14	0.21	0.36	0.196	0.235

PWM

	A	C	G	T
01	-0.622	0.14	0.249	0.03
02	0.776	-0.484	-0.577	-0.432
03	0.66	-1.003	0.417	-1.712
04	-3.609	1.371	-4.127	-4.127
05	1.374	-4.127	-4.127	-4.127
06	-4.127	-2.814	1.363	-4.127
07	-3.609	1.371	-4.127	-4.127
08	-4.127	-4.127	-4.127	1.374
09	-3.269	-3.269	1.363	-4.127
10	-3.269	1.311	-4.127	-1.447
11	-1.447	0.373	-0.945	0.654
12	0.035	-0.163	-0.272	0.303
13	-0.163	0.474	-1.2	0.218
14	-0.173	0.36	-0.241	-0.062

Standard thresholds

P-value	Threshold
0.001	2.55206
0.0005	3.96081
0.0001	6.36456