ASCL2.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ASCL2.H12INVIVO.0.PSM.A
Gene (human)	ASCL2 (GeneCards)
Gene synonyms (human)	BHLHA45, HASH2
Gene (mouse)	Ascl2
Gene synonyms (mouse)	Mash2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	10
Consensus	vCASCTGCYb
GC content	66.53%
Information content (bits; total / per base)	12.274 / 1.227
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	997

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	2 (12)	0.892	0.917	0.823	0.864	0.81	0.84	2.544	2.658	174.897	279.796

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.858	0.831	0.727	0.715	0.626	0.635
Overall, 6 experiments	best	0.959	0.94	0.888	0.864	0.758	0.755
Methyl HT-SELEX, 2 experiments	median	0.887	0.862	0.758	0.744	0.648	0.655
Methyl HT-SELEX, 2 experiments	best	0.895	0.869	0.766	0.751	0.653	0.66
Non-Methyl HT-SELEX, 4 experiments	median	0.754	0.738	0.646	0.643	0.579	0.587
Non-Methyl HT-SELEX, 4 experiments	best	0.959	0.94	0.888	0.864	0.758	0.755

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.665	0.342	0.684	0.482

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	MyoD-ASC-related {1.2.2} (TFClass)
TF subfamily	ASC {1.2.2.2} (TFClass)
TFClass ID	TFClass: 1.2.2.2.2
HGNC	HGNC:739
MGI	MGI:96920
EntrezGene (human)	GeneID:430 (SSTAR profile)
EntrezGene (mouse)	GeneID:17173 (SSTAR profile)
UniProt ID (human)	ASCL2_HUMAN
UniProt ID (mouse)	ASCL2_MOUSE
UniProt AC (human)	Q99929 (TFClass)
UniProt AC (mouse)	O35885 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 2 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	ASCL2.H12INVIVO.0.PSM.A.pcm
PWM	ASCL2.H12INVIVO.0.PSM.A.pwm
PFM	ASCL2.H12INVIVO.0.PSM.A.pfm
Alignment	ASCL2.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	ASCL2.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	ASCL2.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	ASCL2.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	ASCL2.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	ASCL2.H12INVIVO.0.PSM.A_homer_format_0.001.txt ASCL2.H12INVIVO.0.PSM.A_homer_format_0.0005.txt ASCL2.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	299.0	288.0	381.0	29.0
02	9.0	982.0	4.0	2.0
03	976.0	6.0	4.0	11.0
04	6.0	361.0	613.0	17.0
05	7.0	982.0	6.0	2.0
06	46.0	1.0	2.0	948.0
07	2.0	93.0	898.0	4.0
08	2.0	934.0	8.0	53.0
09	128.0	336.0	10.0	523.0
10	81.0	302.0	422.0	192.0

PFM

	A	C	G	T
01	0.3	0.289	0.382	0.029
02	0.009	0.985	0.004	0.002
03	0.979	0.006	0.004	0.011
04	0.006	0.362	0.615	0.017
05	0.007	0.985	0.006	0.002
06	0.046	0.001	0.002	0.951
07	0.002	0.093	0.901	0.004
08	0.002	0.937	0.008	0.053
09	0.128	0.337	0.01	0.525
10	0.081	0.303	0.423	0.193

PWM

	A	C	G	T
01	0.181	0.144	0.422	-2.1
02	-3.153	1.366	-3.78	-4.21
03	1.36	-3.481	-3.78	-2.982
04	-3.481	0.368	0.896	-2.595
05	-3.359	1.366	-3.481	-4.21
06	-1.66	-4.522	-4.21	1.331
07	-4.21	-0.974	1.277	-3.78
08	-4.21	1.316	-3.251	-1.523
09	-0.66	0.297	-3.064	0.738
10	-1.11	0.191	0.524	-0.259

Standard thresholds

P-value	Threshold
0.001	3.873735
0.0005	4.86066
0.0001	7.237345