ASCL2.H12CORE.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ASCL2.H12CORE.0.PSM.A
Gene (human)	ASCL2 (GeneCards)
Gene synonyms (human)	BHLHA45, HASH2
Gene (mouse)	Ascl2
Gene synonyms (mouse)	Mash2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	9
Consensus	vCASCTGCY
GC content	64.52%
Information content (bits; total / per base)	12.283 / 1.365
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	982

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	2 (12)	0.883	0.93	0.824	0.877	0.794	0.855	2.314	2.52	158.542	305.42

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.897	0.869	0.749	0.741	0.638	0.65
Overall, 6 experiments	best	0.969	0.952	0.928	0.906	0.793	0.792
Methyl HT-SELEX, 2 experiments	median	0.926	0.901	0.784	0.774	0.662	0.674
Methyl HT-SELEX, 2 experiments	best	0.932	0.907	0.796	0.784	0.673	0.682
Non-Methyl HT-SELEX, 4 experiments	median	0.78	0.763	0.66	0.659	0.589	0.598
Non-Methyl HT-SELEX, 4 experiments	best	0.969	0.952	0.928	0.906	0.793	0.792

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.68	0.385	0.702	0.501

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	MyoD-ASC-related {1.2.2} (TFClass)
TF subfamily	ASC {1.2.2.2} (TFClass)
TFClass ID	TFClass: 1.2.2.2.2
HGNC	HGNC:739
MGI	MGI:96920
EntrezGene (human)	GeneID:430 (SSTAR profile)
EntrezGene (mouse)	GeneID:17173 (SSTAR profile)
UniProt ID (human)	ASCL2_HUMAN
UniProt ID (mouse)	ASCL2_MOUSE
UniProt AC (human)	Q99929 (TFClass)
UniProt AC (mouse)	O35885 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 2 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	ASCL2.H12CORE.0.PSM.A.pcm
PWM	ASCL2.H12CORE.0.PSM.A.pwm
PFM	ASCL2.H12CORE.0.PSM.A.pfm
Alignment	ASCL2.H12CORE.0.PSM.A.words.tsv
Threshold to P-value map	ASCL2.H12CORE.0.PSM.A.thr
Motif in other formats
JASPAR format	ASCL2.H12CORE.0.PSM.A_jaspar_format.txt
MEME format	ASCL2.H12CORE.0.PSM.A_meme_format.meme
Transfac format	ASCL2.H12CORE.0.PSM.A_transfac_format.txt
Homer format	ASCL2.H12CORE.0.PSM.A_homer_format_0.001.txt ASCL2.H12CORE.0.PSM.A_homer_format_0.0005.txt ASCL2.H12CORE.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	303.0	320.0	316.0	43.0
02	2.0	978.0	0.0	2.0
03	970.0	7.0	1.0	4.0
04	8.0	293.0	621.0	60.0
05	3.0	964.0	12.0	3.0
06	4.0	4.0	0.0	974.0
07	4.0	12.0	961.0	5.0
08	5.0	856.0	27.0	94.0
09	127.0	320.0	10.0	525.0

PFM

	A	C	G	T
01	0.309	0.326	0.322	0.044
02	0.002	0.996	0.0	0.002
03	0.988	0.007	0.001	0.004
04	0.008	0.298	0.632	0.061
05	0.003	0.982	0.012	0.003
06	0.004	0.004	0.0	0.992
07	0.004	0.012	0.979	0.005
08	0.005	0.872	0.027	0.096
09	0.129	0.326	0.01	0.535

PWM

	A	C	G	T
01	0.209	0.263	0.251	-1.71
02	-4.196	1.377	-4.967	-4.196
03	1.369	-3.344	-4.509	-3.766
04	-3.236	0.176	0.924	-1.388
05	-3.958	1.363	-2.891	-3.958
06	-3.766	-3.766	-4.967	1.373
07	-3.766	-2.891	1.359	-3.605
08	-3.605	1.244	-2.153	-0.949
09	-0.653	0.263	-3.049	0.756

Standard thresholds

P-value	Threshold
0.001	3.702265
0.0005	4.70544
0.0001	7.348205