MotifASCL2.H12CORE.0.PSM.A
Gene (human)ASCL2
(GeneCards)
Gene synonyms (human)BHLHA45, HASH2
Gene (mouse)Ascl2
Gene synonyms (mouse)Mash2
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length9
ConsensusvCASCTGCY
GC content64.52%
Information content (bits; total / per base)12.283 / 1.365
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words982

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Mouse 2 (12) 0.883 0.93 0.824 0.877 0.794 0.855 2.314 2.52 158.542 305.42

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.897 0.869 0.749 0.741 0.638 0.65
best 0.969 0.952 0.928 0.906 0.793 0.792
Methyl HT-SELEX, 2 experiments median 0.926 0.901 0.784 0.774 0.662 0.674
best 0.932 0.907 0.796 0.784 0.673 0.682
Non-Methyl HT-SELEX, 4 experiments median 0.78 0.763 0.66 0.659 0.589 0.598
best 0.969 0.952 0.928 0.906 0.793 0.792

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.68 0.385 0.702 0.501
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF familyMyoD-ASC-related {1.2.2} (TFClass)
TF subfamilyASC {1.2.2.2} (TFClass)
TFClass IDTFClass: 1.2.2.2.2
HGNCHGNC:739
MGIMGI:96920
EntrezGene (human)GeneID:430
(SSTAR profile)
EntrezGene (mouse)GeneID:17173
(SSTAR profile)
UniProt ID (human)ASCL2_HUMAN
UniProt ID (mouse)ASCL2_MOUSE
UniProt AC (human)Q99929
(TFClass)
UniProt AC (mouse)O35885
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 2 mouse
HT-SELEX 4
Methyl-HT-SELEX 2
PCM
ACGT
01303.0320.0316.043.0
022.0978.00.02.0
03970.07.01.04.0
048.0293.0621.060.0
053.0964.012.03.0
064.04.00.0974.0
074.012.0961.05.0
085.0856.027.094.0
09127.0320.010.0525.0
PFM
ACGT
010.3090.3260.3220.044
020.0020.9960.00.002
030.9880.0070.0010.004
040.0080.2980.6320.061
050.0030.9820.0120.003
060.0040.0040.00.992
070.0040.0120.9790.005
080.0050.8720.0270.096
090.1290.3260.010.535
PWM
ACGT
010.2090.2630.251-1.71
02-4.1961.377-4.967-4.196
031.369-3.344-4.509-3.766
04-3.2360.1760.924-1.388
05-3.9581.363-2.891-3.958
06-3.766-3.766-4.9671.373
07-3.766-2.8911.359-3.605
08-3.6051.244-2.153-0.949
09-0.6530.263-3.0490.756
Standard thresholds
P-value Threshold
0.001 3.702265
0.0005 4.70544
0.0001 7.348205