ASCL1.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ASCL1.H12INVIVO.0.PSM.A
Gene (human)	ASCL1 (GeneCards)
Gene synonyms (human)	ASH1, BHLHA46, HASH1
Gene (mouse)	Ascl1
Gene synonyms (mouse)	Ash1, Mash-1, Mash1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	13
Consensus	vCASCTGYhnbhn
GC content	61.91%
Information content (bits; total / per base)	11.267 / 0.867
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	984

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	14 (78)	0.902	0.966	0.808	0.903	0.873	0.95	2.972	3.72	232.894	366.509
Mouse	11 (68)	0.944	0.981	0.873	0.956	0.898	0.944	3.032	3.529	251.176	485.638

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.934	0.896	0.848	0.819	0.719	0.717
Overall, 2 experiments	best	0.95	0.92	0.884	0.854	0.748	0.745
Methyl HT-SELEX, 1 experiments	median	0.918	0.871	0.813	0.783	0.69	0.688
Methyl HT-SELEX, 1 experiments	best	0.918	0.871	0.813	0.783	0.69	0.688
Non-Methyl HT-SELEX, 1 experiments	median	0.95	0.92	0.884	0.854	0.748	0.745
Non-Methyl HT-SELEX, 1 experiments	best	0.95	0.92	0.884	0.854	0.748	0.745

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	9.457	3.244	0.333	0.183

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.521	0.034	0.309	0.216

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	MyoD-ASC-related {1.2.2} (TFClass)
TF subfamily	ASC {1.2.2.2} (TFClass)
TFClass ID	TFClass: 1.2.2.2.1
HGNC	HGNC:738
MGI	MGI:96919
EntrezGene (human)	GeneID:429 (SSTAR profile)
EntrezGene (mouse)	GeneID:17172 (SSTAR profile)
UniProt ID (human)	ASCL1_HUMAN
UniProt ID (mouse)	ASCL1_MOUSE
UniProt AC (human)	P50553 (TFClass)
UniProt AC (mouse)	Q02067 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	14 human, 11 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	ASCL1.H12INVIVO.0.PSM.A.pcm
PWM	ASCL1.H12INVIVO.0.PSM.A.pwm
PFM	ASCL1.H12INVIVO.0.PSM.A.pfm
Alignment	ASCL1.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	ASCL1.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	ASCL1.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	ASCL1.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	ASCL1.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	ASCL1.H12INVIVO.0.PSM.A_homer_format_0.001.txt ASCL1.H12INVIVO.0.PSM.A_homer_format_0.0005.txt ASCL1.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	280.0	269.0	332.0	103.0
02	12.0	956.0	8.0	8.0
03	938.0	8.0	10.0	28.0
04	0.0	445.0	498.0	41.0
05	8.0	952.0	18.0	6.0
06	3.0	0.0	3.0	978.0
07	5.0	8.0	967.0	4.0
08	18.0	706.0	122.0	138.0
09	147.0	431.0	31.0	375.0
10	190.0	299.0	238.0	257.0
11	144.0	408.0	179.0	253.0
12	209.0	379.0	133.0	263.0
13	200.0	270.0	249.0	265.0

PFM

	A	C	G	T
01	0.285	0.273	0.337	0.105
02	0.012	0.972	0.008	0.008
03	0.953	0.008	0.01	0.028
04	0.0	0.452	0.506	0.042
05	0.008	0.967	0.018	0.006
06	0.003	0.0	0.003	0.994
07	0.005	0.008	0.983	0.004
08	0.018	0.717	0.124	0.14
09	0.149	0.438	0.032	0.381
10	0.193	0.304	0.242	0.261
11	0.146	0.415	0.182	0.257
12	0.212	0.385	0.135	0.267
13	0.203	0.274	0.253	0.269

PWM

	A	C	G	T
01	0.129	0.089	0.298	-0.861
02	-2.893	1.352	-3.238	-3.238
03	1.333	-3.238	-3.051	-2.12
04	-4.968	0.59	0.702	-1.758
05	-3.238	1.348	-2.531	-3.468
06	-3.96	-4.968	-3.96	1.375
07	-3.607	-3.238	1.364	-3.768
08	-2.531	1.05	-0.694	-0.573
09	-0.51	0.558	-2.024	0.419
10	-0.256	0.194	-0.033	0.043
11	-0.531	0.503	-0.315	0.028
12	-0.162	0.43	-0.609	0.066
13	-0.205	0.092	0.012	0.074

Standard thresholds

P-value	Threshold
0.001	4.19726
0.0005	5.149615
0.0001	7.638575