ASCL1.H12CORE.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ASCL1.H12CORE.0.PSM.A
Gene (human)	ASCL1 (GeneCards)
Gene synonyms (human)	ASH1, BHLHA46, HASH1
Gene (mouse)	Ascl1
Gene synonyms (mouse)	Ash1, Mash-1, Mash1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	nvCAKCTGYhn
GC content	59.26%
Information content (bits; total / per base)	11.144 / 1.013
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9507

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	14 (78)	0.895	0.963	0.792	0.91	0.807	0.921	2.349	3.221	210.659	332.921
Mouse	11 (68)	0.945	0.986	0.873	0.967	0.887	0.944	2.86	3.479	244.045	471.032

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.959	0.942	0.853	0.842	0.708	0.723
Overall, 2 experiments	best	0.967	0.949	0.9	0.88	0.745	0.755
Methyl HT-SELEX, 1 experiments	median	0.952	0.935	0.807	0.804	0.672	0.691
Methyl HT-SELEX, 1 experiments	best	0.952	0.935	0.807	0.804	0.672	0.691
Non-Methyl HT-SELEX, 1 experiments	median	0.967	0.949	0.9	0.88	0.745	0.755
Non-Methyl HT-SELEX, 1 experiments	best	0.967	0.949	0.9	0.88	0.745	0.755

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	100.0	5.316	0.371	0.184

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.511	0.034	0.161	0.205

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	MyoD-ASC-related {1.2.2} (TFClass)
TF subfamily	ASC {1.2.2.2} (TFClass)
TFClass ID	TFClass: 1.2.2.2.1
HGNC	HGNC:738
MGI	MGI:96919
EntrezGene (human)	GeneID:429 (SSTAR profile)
EntrezGene (mouse)	GeneID:17172 (SSTAR profile)
UniProt ID (human)	ASCL1_HUMAN
UniProt ID (mouse)	ASCL1_MOUSE
UniProt AC (human)	P50553 (TFClass)
UniProt AC (mouse)	Q02067 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	14 human, 11 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	ASCL1.H12CORE.0.PSM.A.pcm
PWM	ASCL1.H12CORE.0.PSM.A.pwm
PFM	ASCL1.H12CORE.0.PSM.A.pfm
Alignment	ASCL1.H12CORE.0.PSM.A.words.tsv
Threshold to P-value map	ASCL1.H12CORE.0.PSM.A.thr
Motif in other formats
JASPAR format	ASCL1.H12CORE.0.PSM.A_jaspar_format.txt
MEME format	ASCL1.H12CORE.0.PSM.A_meme_format.meme
Transfac format	ASCL1.H12CORE.0.PSM.A_transfac_format.txt
Homer format	ASCL1.H12CORE.0.PSM.A_homer_format_0.001.txt ASCL1.H12CORE.0.PSM.A_homer_format_0.0005.txt ASCL1.H12CORE.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2642.75	1962.75	2974.75	1926.75
02	3092.25	2558.25	2994.25	862.25
03	272.0	8700.0	209.0	326.0
04	9141.0	81.0	40.0	245.0
05	2.0	1226.0	6187.0	2092.0
06	5.0	9502.0	0.0	0.0
07	0.0	1.0	0.0	9506.0
08	14.0	56.0	9346.0	91.0
09	176.0	7083.0	298.0	1950.0
10	1042.5	2857.5	964.5	4642.5
11	2157.75	2794.75	2137.75	2416.75

PFM

	A	C	G	T
01	0.278	0.206	0.313	0.203
02	0.325	0.269	0.315	0.091
03	0.029	0.915	0.022	0.034
04	0.962	0.009	0.004	0.026
05	0.0	0.129	0.651	0.22
06	0.001	0.999	0.0	0.0
07	0.0	0.0	0.0	1.0
08	0.001	0.006	0.983	0.01
09	0.019	0.745	0.031	0.205
10	0.11	0.301	0.101	0.488
11	0.227	0.294	0.225	0.254

PWM

	A	C	G	T
01	0.106	-0.191	0.224	-0.21
02	0.263	0.074	0.231	-1.012
03	-2.16	1.297	-2.421	-1.981
04	1.346	-3.352	-4.03	-2.264
05	-6.318	-0.661	0.956	-0.127
06	-5.788	1.385	-6.946	-6.946
07	-6.946	-6.584	-6.946	1.385
08	-4.984	-3.709	1.368	-3.239
09	-2.591	1.091	-2.07	-0.198
10	-0.823	0.184	-0.9	0.669
11	-0.097	0.162	-0.106	0.017

Standard thresholds

P-value	Threshold
0.001	4.279525
0.0005	5.2655
0.0001	7.823125