MotifAP2C.H12INVIVO.0.PSM.A
Gene (human)TFAP2C
(GeneCards)
Gene synonyms (human)
Gene (mouse)Tfap2c
Gene synonyms (mouse)Tcfap2c
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length15
ConsensusvddSCCYGRGGShdb
GC content67.12%
Information content (bits; total / per base)11.743 / 0.783
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words922

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 24 (141) 0.875 0.939 0.747 0.86 0.822 0.89 2.476 2.994 147.041 404.292
Mouse 4 (25) 0.899 0.913 0.756 0.796 0.785 0.818 2.068 2.394 151.921 206.252

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 5 experiments median 0.961 0.934 0.95 0.918 0.807 0.838
best 0.998 0.997 0.996 0.994 0.927 0.896
Methyl HT-SELEX, 1 experiments median 0.961 0.934 0.95 0.918 0.927 0.891
best 0.961 0.934 0.95 0.918 0.927 0.891
Non-Methyl HT-SELEX, 4 experiments median 0.826 0.84 0.756 0.778 0.649 0.686
best 0.998 0.997 0.996 0.994 0.873 0.896

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 2.891 3.352 0.202 0.12
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-span-helix factors (bHSH) {1.3} (TFClass)
TF familyAP-2 {1.3.1} (TFClass)
TF subfamily {1.3.1.0} (TFClass)
TFClass IDTFClass: 1.3.1.0.3
HGNCHGNC:11744
MGIMGI:106032
EntrezGene (human)GeneID:7022
(SSTAR profile)
EntrezGene (mouse)GeneID:21420
(SSTAR profile)
UniProt ID (human)AP2C_HUMAN
UniProt ID (mouse)AP2C_MOUSE
UniProt AC (human)Q92754
(TFClass)
UniProt AC (mouse)Q61312
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 24 human, 4 mouse
HT-SELEX 4
Methyl-HT-SELEX 1
PCM
ACGT
01376.0195.0224.0127.0
02167.0159.0175.0421.0
03198.0108.0423.0193.0
0418.0471.0415.018.0
050.0911.01.010.0
069.0870.04.039.0
0753.0169.028.0672.0
080.00.0817.0105.0
09430.081.0398.013.0
10130.00.0789.03.0
112.02.0909.09.0
1249.0495.0345.033.0
13183.0363.0141.0235.0
14386.0161.0212.0163.0
15140.0186.0231.0365.0
PFM
ACGT
010.4080.2110.2430.138
020.1810.1720.190.457
030.2150.1170.4590.209
040.020.5110.450.02
050.00.9880.0010.011
060.010.9440.0040.042
070.0570.1830.030.729
080.00.00.8860.114
090.4660.0880.4320.014
100.1410.00.8560.003
110.0020.0020.9860.01
120.0530.5370.3740.036
130.1980.3940.1530.255
140.4190.1750.230.177
150.1520.2020.2510.396
PWM
ACGT
010.486-0.166-0.028-0.59
02-0.319-0.368-0.2730.599
03-0.151-0.750.604-0.176
04-2.4670.7110.585-2.467
05-4.9131.369-4.452-2.987
06-3.0771.323-3.706-1.741
07-1.446-0.308-2.0561.065
08-4.913-4.9131.26-0.778
090.62-1.0320.543-2.759
10-0.567-4.9131.225-3.899
11-4.138-4.1381.367-3.077
12-1.5220.760.401-1.901
13-0.2290.451-0.4870.019
140.513-0.356-0.083-0.343
15-0.494-0.2130.0020.457
Standard thresholds
P-value Threshold
0.001 4.18776
0.0005 5.25946
0.0001 7.38356