MotifAP2C.H12CORE.0.PSM.A
Gene (human)TFAP2C
(GeneCards)
Gene synonyms (human)
Gene (mouse)Tfap2c
Gene synonyms (mouse)Tcfap2c
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length15
ConsensusnndWnSCCTSRGGSn
GC content62.95%
Information content (bits; total / per base)12.394 / 0.826
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9683

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 24 (141) 0.887 0.942 0.764 0.874 0.772 0.854 2.146 2.725 136.721 404.18
Mouse 4 (25) 0.898 0.917 0.757 0.8 0.715 0.762 1.767 2.059 147.398 189.42

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 5 experiments median 0.972 0.961 0.955 0.927 0.836 0.862
best 0.999 0.998 0.998 0.996 0.928 0.918
Methyl HT-SELEX, 1 experiments median 0.967 0.944 0.955 0.927 0.928 0.896
best 0.967 0.944 0.955 0.927 0.928 0.896
Non-Methyl HT-SELEX, 4 experiments median 0.984 0.978 0.897 0.9 0.734 0.771
best 0.999 0.998 0.998 0.996 0.9 0.918

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 3.733 4.646 0.186 0.113
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-span-helix factors (bHSH) {1.3} (TFClass)
TF familyAP-2 {1.3.1} (TFClass)
TF subfamily {1.3.1.0} (TFClass)
TFClass IDTFClass: 1.3.1.0.3
HGNCHGNC:11744
MGIMGI:106032
EntrezGene (human)GeneID:7022
(SSTAR profile)
EntrezGene (mouse)GeneID:21420
(SSTAR profile)
UniProt ID (human)AP2C_HUMAN
UniProt ID (mouse)AP2C_MOUSE
UniProt AC (human)Q92754
(TFClass)
UniProt AC (mouse)Q61312
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 24 human, 4 mouse
HT-SELEX 4
Methyl-HT-SELEX 1
PCM
ACGT
013564.251493.252289.252336.25
023305.751757.751527.753091.75
035521.0562.01509.02091.0
042271.0788.0556.06068.0
051702.02863.02265.02853.0
0664.03075.06491.053.0
075.09672.02.04.0
080.09682.00.01.0
093.01952.092.07636.0
10537.04110.04474.0562.0
116095.0803.02736.049.0
12784.059.08796.044.0
1397.079.09420.087.0
14352.254705.254092.25533.25
151947.03043.02530.02163.0
PFM
ACGT
010.3680.1540.2360.241
020.3410.1820.1580.319
030.570.0580.1560.216
040.2350.0810.0570.627
050.1760.2960.2340.295
060.0070.3180.670.005
070.0010.9990.00.0
080.01.00.00.0
090.00.2020.010.789
100.0550.4240.4620.058
110.6290.0830.2830.005
120.0810.0060.9080.005
130.010.0080.9730.009
140.0360.4860.4230.055
150.2010.3140.2610.223
PWM
ACGT
010.387-0.483-0.056-0.035
020.311-0.32-0.460.244
030.824-1.457-0.472-0.146
04-0.064-1.12-1.4680.918
05-0.3520.168-0.0660.164
06-3.5990.2390.986-3.78
07-5.8061.384-6.335-5.953
08-6.9621.385-6.962-6.601
09-6.126-0.215-3.2461.148
10-1.5030.5290.614-1.457
110.923-1.1020.122-3.855
12-1.125-3.6771.29-3.958
13-3.195-3.3951.358-3.301
14-1.9220.6640.525-1.509
15-0.2180.2290.044-0.112
Standard thresholds
P-value Threshold
0.001 3.64856
0.0005 4.91081
0.0001 7.35376