MotifAP2A.H12INVIVO.0.PSM.A
Gene (human)TFAP2A
(GeneCards)
Gene synonyms (human)AP2TF, TFAP2
Gene (mouse)Tfap2a
Gene synonyms (mouse)Ap2tf, Tcfap2a
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length14
ConsensusnhnSCCYGRGGSnd
GC content66.91%
Information content (bits; total / per base)11.853 / 0.847
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words957

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 10 (58) 0.894 0.964 0.787 0.919 0.828 0.902 2.61 3.159 206.011 449.114
Mouse 5 (34) 0.933 0.956 0.841 0.892 0.86 0.908 2.808 3.358 341.601 484.959

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 7 experiments median 0.989 0.983 0.871 0.878 0.678 0.724
best 0.998 0.997 0.997 0.996 0.995 0.992
Methyl HT-SELEX, 1 experiments median 0.998 0.997 0.997 0.996 0.995 0.992
best 0.998 0.997 0.997 0.996 0.995 0.992
Non-Methyl HT-SELEX, 6 experiments median 0.981 0.973 0.846 0.853 0.672 0.712
best 0.996 0.994 0.991 0.986 0.985 0.977

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 26.653 5.972 0.381 0.174
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-span-helix factors (bHSH) {1.3} (TFClass)
TF familyAP-2 {1.3.1} (TFClass)
TF subfamily {1.3.1.0} (TFClass)
TFClass IDTFClass: 1.3.1.0.1
HGNCHGNC:11742
MGIMGI:104671
EntrezGene (human)GeneID:7020
(SSTAR profile)
EntrezGene (mouse)GeneID:21418
(SSTAR profile)
UniProt ID (human)AP2A_HUMAN
UniProt ID (mouse)AP2A_MOUSE
UniProt AC (human)P05549
(TFClass)
UniProt AC (mouse)P34056
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 10 human, 5 mouse
HT-SELEX 6
Methyl-HT-SELEX 1
PCM
ACGT
01355.0231.0189.0182.0
02163.0149.0130.0515.0
03214.0145.0368.0230.0
0413.0469.0442.033.0
050.0947.03.07.0
062.0904.01.050.0
0749.0216.021.0671.0
08140.00.0817.00.0
09476.071.0399.011.0
10171.01.0783.02.0
113.01.0949.04.0
1222.0496.0426.013.0
13250.0345.0139.0223.0
14490.0124.0198.0145.0
PFM
ACGT
010.3710.2410.1970.19
020.170.1560.1360.538
030.2240.1520.3850.24
040.0140.490.4620.034
050.00.990.0030.007
060.0020.9450.0010.052
070.0510.2260.0220.701
080.1460.00.8540.0
090.4970.0740.4170.011
100.1790.0010.8180.002
110.0030.0010.9920.004
120.0230.5180.4450.014
130.2610.3610.1450.233
140.5120.130.2070.152
PWM
ACGT
010.392-0.035-0.234-0.271
02-0.38-0.469-0.6040.763
03-0.111-0.4960.428-0.039
04-2.7960.670.611-1.937
05-4.9451.37-3.934-3.32
06-4.1721.324-4.486-1.539
07-1.558-0.101-2.3621.027
08-0.531-4.9451.223-4.945
090.684-1.1980.509-2.942
10-0.333-4.4861.181-4.172
11-3.934-4.4861.373-3.741
12-2.3190.7250.574-2.796
130.0440.364-0.538-0.07
140.713-0.651-0.188-0.496
Standard thresholds
P-value Threshold
0.001 4.08016
0.0005 5.21296
0.0001 7.43676